While it may be called morning sickness, nausea and vomiting can hit any time of day or night and are one of the most common and dreaded pregnancy symptoms. Nausea can wreak havoc on your life during the first trimester, sometimes into your second trimester, and in some cases, throughout your entire pregnancy. What Causes Nausea and Vomiting in Pregnancy? Hormones - progesterone, estrogen, and human chorionic gonadotropin (hCG) rise significantly in pregnancy. As the placent